Growth Differentiation Factor 5 Is A Paracrine Regulator In Sarcopenic Obesity
نویسندگان
چکیده
Sarcopenic obesity (SO) differentiates itself from sarcopenia and by exhibiting a more detrimental complex condition that increases the risk of mortality in aging individuals. obese individuals suffer greater physical disability muscle weakness than sarcopenic alone. In addition, altered cellular signaling regulates increased loss SO is largely unknown. Identifying key differentially expressed genes are important for future investigation creation therapeutics strategies aimed at attenuating or preventing loss. PURPOSE: To examine global gene expression mice to determine (DE) genes. METHODS: After weaning, twenty-four were randomly assigned young (3-4 months old) aged (22-24 groups then either high-fat (HFD, 60% fat) normal chow (NC, 14% diet. RNA was isolated plantaris Next Generation sequencing bioinformatics conducted DE among experimental groups. Log2FoldChange (FC) ≥ 0.6, Log2FC ≤ -0.6 p 0.05 criteria used significant Real-Time Polymerase Chain Reaction confirm mRNA RESULTS: Aged-HFD had an ̴ 39-49% (p 0.05) reduction body mass ratio compared all other CYP1A1, RAB15, CDH22 showed main effects Age diet interacted alter GDF5 abundance. There 26-fold increase GDF-5 abundance aged-HFD CONCLUSION: associated with TGF-B SMAD signaling. The seen could be promoting collagen deposition within skeletal affecting function. These findings show may play role atrophy SO.
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ژورنال
عنوان ژورنال: Medicine and Science in Sports and Exercise
سال: 2022
ISSN: ['1530-0315', '0195-9131']
DOI: https://doi.org/10.1249/01.mss.0000883496.95250.12